বৃহস্পতিবার, ২৮ মার্চ, ২০১৩

Aastrom Biosciences ends drug trial, to cut half its workforce

Mar 26 (Reuters) - Leading money winners on the 2013 PGATour on Monday (U.S. unless stated): 1. Tiger Woods $3,787,600 2. Brandt Snedeker $2,859,920 3. Matt Kuchar $2,154,500 4. Steve Stricker $1,820,000 5. Phil Mickelson $1,650,260 6. Hunter Mahan $1,553,965 7. John Merrick $1,343,514 8. Dustin Johnson $1,330,507 9. Russell Henley $1,313,280 10. Kevin Streelman $1,310,343 11. Keegan Bradley $1,274,593 12. Charles Howell III $1,256,373 13. Michael Thompson $1,254,669 14. Brian Gay $1,171,721 15. Justin Rose $1,155,550 16. Jason Day $1,115,565 17. Chris Kirk $1,097,053 18. ...

Source: http://news.yahoo.com/aastrom-biosciences-ends-drug-trial-cut-half-workforce-130941288--sector.html

Mens Gymnastics Allison Schmitt Olympic Schedule Kyla Ross Ryan Lochte Montenegro Olympic Games

WADA backs HGH test against 'extremist' NFLPA

By STEPHEN WILSON

AP Sports Writer

Associated Press Sports

updated 12:29 p.m. ET March 27, 2013

LONDON (AP) - The World Anti-Doping Agency has defended its test for human growth hormone and accused the NFL players union of being "extremist" for questioning its validity.

WADA director general David Howman tells The Associated Press the test for HGH was endorsed by the Court of Arbitration for Sport in its ruling Tuesday in the case of an Estonian cross-country skier.

The court lifted the three-year suspension imposed by the International Ski Federation on two-time Olympic cross-country champion Andrus Veerpalu for use of HGH, citing "procedural flaws." But CAS said it believed Veerpalu did take HGH and backed the testing method.

Howman says "there is no question as to the validity of the test."

The NFL players union said the CAS ruling "validates the players' demands for scientific validity, full due process rights, and a transparent system."

Howman says "I would expect the players association to take a stance which is extremist which is the way they've operated the last few years."

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


advertisement

More news
Is Geno Smith worthy of top 10?

??PFT Live: The Chiefs are interested in drafting the QB, but Mike Smith believes it would be smart for the Chiefs to trade the No. 1 pick.

PFT: Getting to know Alabama's Lacy

??ProFootballTalk: Alabama is also known for producing standout running backs, and Eddie Lacy is the latest to emerge, with hopes he follows in the footsteps of Mark Ingram and Trent Richardson.

Source: http://nbcsports.msnbc.com/id/51350789/ns/sports-nfl/

texas news kim mulkey sarah palin today show dallas tornado video 1940 census instagram for android dallas news

Ind. blast suspect charged in plot to kill witness

INDIANAPOLIS (AP) ? An Indianapolis man facing trial in a house explosion that killed two people and damaged or destroyed dozens of homes was charged Thursday with plotting to have a witness in the case killed.

Marion County Prosecutor Terry Curry announced Mark Leonard had been charged with one count of conspiracy to commit murder during a news conference in downtown Indianapolis.

Curry said Leonard tried to arrange to have the witness killed for a payment of $15,000. Curry said Leonard also offered a $5,000 bonus if the killing was made to look like a suicide and if the killer could force the witness to first call 911 and recant statements about the explosion.

Leonard, girlfriend Monserrate Shirley and brother Bob Leonard are awaiting trial in the Nov. 10 blast that killed a teacher and her husband, and left 33 homes in the Richmond Hill subdivision so damaged that they had to be demolished.

Investigators say the trio intentionally created a gas explosion in Shirley's home in hopes of collecting insurance money. A microwave set to start on a timer sparked the explosion in Shirley's gas-filled home after a gas fireplace valve and a gas line regulator in the house were removed.

John and Jennifer Longworth died after the explosion ignited another explosion and resulting fire at their house.

All three defendants face murder, arson and conspiracy charges. Shirley also is charged with insurance fraud.

Curry said in February he would see life without parole for Shirley and the Leonards because a jury was unlikely to choose the death penalty.

Source: http://news.yahoo.com/ind-blast-suspect-charged-plot-kill-witness-145805068.html

friends with kids pacific standard time northern mariana islands summer time coolio ricky rubio day light savings time

BMW and Mini cars add iOS integration for Audible, Glympse, Rhapsody and TuneIn

Glympse to offer incar location sharing, fewer excuses for BMW and Mini drivers

BMW hasn't been quite as aggressive in pushing smartphone app integration as American counterparts like Ford or GM, but it certainly knows how to make up for lost time: the Munich automaker just greenlit tie-ins with the iOS apps from Audible, Glympse, Rhapsody and TuneIn. Plug in a device and it will be possible to wield the apps' respective audiobook, location sharing, subscription music and live streaming radio services from a BMW Apps-capable BMW or Mini, with an interface optimized for the center stack. Each of the developers will need to update their app to make everything click, which we're told may take weeks. There still shouldn't be much wait before fans of Teutonic (and British) rides can get lost while streaming favorite songs -- and tell everyone just how far they went off-course.

Filed under: , ,

Comments

Source: BMW

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/9J_WEGhO0MI/

rand paul Iron Man 3 Lauren Silberman Sim City Manchester United Alvin Lee nicki minaj

Michael Kiwanuka To Play Wellington | Stuff.co.nz

michael kiwanuka

ALWAYS WAITING: "I didn't know if I could sing. But then I gave it a go," says British singer-songwriter Michael Kiwanuka.

New stars often get compared to their music industry forebears and British singer-songwriter Michael Kiwanuka, who plays two shows in New Zealand next month, is no exception.

At just 24 he's garnered comparisons to Otis Reading, Marvin Gaye and Bill Withers ? whom Kiwanuka got to meet last year. The funny thing is that London-born Kiwanuka ? his parents emigrated from Uganda ? doesn't fit neatly in the soul and funk box with Reading, Gaye or Withers.

There's also a strong folk and rock side to Kiwanuka's sound, tipping its hat to, or echoing, Bob Dylan and Paul Simon as well as Roberta Flack and Shuggie Otis.

"It's a little bit annoying," Kiwanuka says about the comparisons. "But it happens so much ? and it is true. The first time round your influences are strong. But after a while [the comparisons] get kind of frustrating. But it's down to me I guess. The more music I make, it will disappear."

Kiwanuka says this without a trace of braggadocio ? even though he'd be justified. He won the prestigious BBC Sound of 2012 and was a Mercury Prize nominee for his debut album Home Again last year. Instead, for a singer-songwriter thrust into the spotlight, he is surprisingly humble and pokes fun at himself.

It includes him opening several times for the mega-selling Adele. "There was no pressure for me. No-one knew who the hell I was. I was the guy with the strange surname."

But Kiwanuka says he learned a lot ? not only from having to perform to big crowds, but watching how Adele and her audience connected, and the scale of how her tour was put together. "It was so exciting. It was like, 'Wow man, I can do this'."

Kiwanuka appreciates that it could have been so different. He says when he was about 13 he had vague aspirations to be a musician. "But to be an artist or a singer ? that seemed, like, impossible. I liked buying CDs at the time ? when I could afford them ? because they were expensive in England. I used to wake up a bit earlier [at home], not because I wanted to go to school, but so I could listen to music a bit more before I went to school. I still do. It's my biggest passion."

Kiwanuka first focused on playing guitar "and being in other people's bands or the guitar playing behind the singer". The shift to centre stage was gradual. "I didn't know if I could sing. But then I gave it a go when I was 21 years old and people liked it and I thought 'I'm going to do that'."

Kiwanuka says he was also open to listening to all kinds of music ? Nirvana was an early favourite ? and continues to do so. "It seems strange now though that I do do that. You didn't care about anything.

"It didn't matter if it was old, new, rock, blues, jazz. It's just music and it seems that the more I get into it, as a professional and an artist, the more it becomes profound and important for me. It's like a first night craving.

THE DETAILS

Michael Kiwanuka plays Holy Trinity Cathedral in Auckland on April 4, and Old St Paul's, Wellington, on April 5

?

- ? Fairfax NZ News

Comments

Source: http://www.stuff.co.nz/entertainment/music/8478130/Kiwanuka-has-eyes-wide-open

Patti Page anonymous texas chainsaw massacre nfl playoffs crystal harris Texas A Texas A&m

শনিবার, ৯ মার্চ, ২০১৩

Fed: Nation's largest banks have strengthened

WASHINGTON (AP) ? All but one of the nation's 18 largest banks are more prepared to withstand a severe U.S. recession and a global downturn than at any time since the 2008 financial crisis, the Federal Reserve says.

Results of the Fed's annual "stress tests" showed Thursday that as a group, the 18 banks hold fewer bad loans compared with last year, thanks to a stronger economy. The Fed will announce next week whether it will approve the banks' plans to increase dividends or repurchase shares.

The Fed's data show that one of the banks, Ally Financial Inc., would have a much lower capital buffer against losses than the others under the most severe scenario. Ally's projected capital level is below the minimum that the Fed considers a bank would need to survive a severe recession.

But Fed officials wouldn't say whether that means it would reject Ally's request for issuing dividends or buying back shares, if Ally were to make one.

Last year, government-owned Ally ? the former financial arm of General Motors ? was the worst-performing bank in the Fed's stress tests. It was one of four banks that failed the tests and were not allowed to raise their dividends or repurchase shares. The others were Citigroup Inc., SunTrust Banks Inc. and MetLife Inc., which has since sold its banking operations and is no longer tested.

Citigroup objected to any characterization that it had failed the 2012 test. It said it had enough capital to withstand the Fed's crisis scenario, just not enough to do that and raise its dividend at the same time.

In a statement, Ally countered that it is well-capitalized and called the Fed's analysis for calculating the bank's potential losses "fundamentally flawed."

"While Ally appreciates the Fed's role in ensuring that financial institutions have adequate capital during stressed situations, using flawed assumptions could have lasting adverse impacts on the economy, including ultimately causing banks to reduce certain key lending categories," the bank said.

The 18 banks were tested on how they would withstand severe downturns not only in the United States but also in Europe and in Asian countries including China and Japan.

Under the stress tests' most severe scenario, the United States would undergo a recession in which unemployment would reach nearly 12 percent, stocks would lose half their value and home prices would plunge 20 percent.

The Fed said that under that crisis scenario, the 18 banks would suffer combined losses of $462 billion through the fourth quarter of 2014.

The Fed has conducted stress tests of the largest banks every year since 2009 in the aftermath of the financial crisis.

Next Thursday, the Fed will announce whether it has approved each bank's request, if one has been made, to raise dividends for its shareholders. Its decisions will be based on how each bank would fare in a severe recession if it increased its dividends.

"The stress tests are a tool to gauge the resiliency of the financial sector," Daniel Tarullo, a Fed governor, said in a statement.

Tarullo said significant increases in the amount and quality of banks' capital cushions against risk "help ensure that banks can continue to lend to consumers and businesses, even in times of economic difficulty."

The 18 banks, along with hundreds of other U.S. banks, received federal bailouts during the financial crisis that struck in 2008 and triggered the worst economic downturn since the Great Depression of the 1930s. The banking industry has been recovering steadily since then, with overall profits rising and banks starting to lend more freely.

Many longtime bank shareholders are unhappy with their investments, because most banks' stock prices still have yet to return to pre-crisis levels. But raising dividends costs a bank cash. The government doesn't want banks to deplete their capital reserves so much that they'd become vulnerable to another recession.

Citigroup and Bank of America Corp. are each still paying shareholders only a token dividend of 1 penny, because the government hasn't allowed them to raise it.

Citigroup said Thursday that it has asked the Fed for permission to buy back $1.2 billion of its stock. The bank did not ask to raise its dividend.

Bank of America, Morgan Stanley, Wells Fargo & Co., Goldman Sachs Group Inc., BB&T Corp., JP Morgan Chase & Co., and U.S. Bancorp released the results of their own stress tests, using the scenario that the Fed had envisioned. They all predicted that their capital levels would be higher than the Fed's estimate.

Citigroup, by contrast, predicted that its capital level would be slightly lower than the Fed's estimate, though still meeting regulatory requirements.

Wells Fargo noted that the Fed doesn't fully disclose its models and methodologies for the stress tests. "As a result, we are unable to explain the basis for any variances between our projections and the projections of the Federal Reserve," the bank said.

Some experts say they aren't sure that even a thumb's-up from the stress tests carries much significance. The industry is no longer in dire shape, but it's still under pressure. Uncertain legal fees and new regulations are restraining profits and revenue, and demand for loans has been generally lackluster.

Chris Whalen, a New York-based analyst, argued that the Fed appears too eager for banks to return capital to shareholders. He said the industry still faces problems.

"Weak profitability and slow revenue growth should be the key areas of concern in the (stress test) analysis, but there will be no discussion of these factors," Whalen wrote in a post shortly before the results were released.

The other banks tested were American Express Co., Bank of New York Mellon Corp., Capital One Financial Corp., Fifth Third Bancorp, KeyCorp, PNC Financial Services Group Inc., Regions Financial Corp. and State Street Corp.

__

Rexrode reported from New York.

Source: http://news.yahoo.com/fed-says-17-18-top-us-banks-strengthened-230501719--finance.html

nfl scores Devon Walker Tom Cruise ryan reynolds Star Trek: The Original Series Carlton Morgan Freeman Dead

শুক্রবার, ৮ মার্চ, ২০১৩

Scientists find more precise way to turn off genes, a major goal of treatments that target cancer

Mar. 7, 2013 ? Scientists at UC San Francisco have found a more precise way to turn off genes, a finding that will speed research discoveries and biotech advances and may eventually prove useful in reprogramming cells to regenerate organs and tissues.

The strategy borrows from the molecular toolbox of bacteria, using a protein employed by microbes to fight off viruses, according to the researchers, who describe the technique in the current issue of Cell.

Turning off genes is a major goal of treatments that target cancer and other diseases. In addition, the ability to turn genes off to learn more about how cells work is a key to unlocking the mysteries of biochemical pathways and interactions that drive normal development as well as disease progression.

"We've spent energy and effort to map the human genome, but we don't yet understand how the genetic blueprint leads to a human being, and how we can manipulate the genome to better understand and treat disease," said Wendell Lim, PhD, a senior author of the study. Lim is director of the UCSF Center for Systems and Synthetic Biology, a Howard Hughes Medical Investigator and professor of cellular and molecular pharmacology.

The new technology developed by the team of UCSF and UC Berkeley researchers is called CRISPR interference -- not to be confused with RNA interference, an already popular strategy for turning off protein production.

"CRISPR interference is a simple approach for selectively perturbing gene expression on a genome-wide scale," said Lei Stanley Qi, PhD, a UCSF Systems Biology Fellow who was the lead author of the Cell study. "This technology is an elegant way to search for any short DNA sequence in the genome, and to then control the expression of the gene where that sequence is located."

The technique will allow researchers to more easily and accurately trace patterns of gene activation and biochemical chains of events that take place within cells, Qi said, and will help scientists identify key proteins that normally control these events and that may go awry in disease.

CRISPR Interference vs. RNA Interference

Unlike conventional RNA interference techniques, CRISPR interference allows any number of individual genes to be silenced at the same time, Qi said. In addition, it acts more crisply, if you will, by not turning off untargeted genes the way RNA interference techniques do.

Gene switching by RNA interference was identified more than a decade ago, launching a new research field that has spawned a Nobel Prize and billion-dollar biotech firms. In January, the U.S. Food and Drug Administration announced its first approval of an injectable disease therapy based on a similar interference strategy, a drug to treat a rare form of high cholesterol.

RNA interference blocks the messenger RNA that drives protein protection based on the blueprint contained within a gene's DNA sequence. By preventing protein production, RNA interference may be used to get around the problem of difficult-to-target proteins, a frequent challenge in drug development.

But CRISPR interference acts one step earlier in the cell's protein manufacturing process. "The horse has already left the barn with RNA interference, in the sense that the RNA message already has been transcribed from DNA," said Jonathan Weissman, PhD, a Howard Hughes Medical Investigator and professor of cellular and molecular pharmacology, who is another senior author on the work. "With CRISPR interference, we can prevent the message from being written."

Implications for Regenerative Medicine

CRISPR -- an acronym for "clustered regularly interspaced short palindromic repeats" -- is a system that bacteria use to defend themselves against viruses. CRISPR acts like a vaccine, incorporating bits of genes from viruses. Bacteria can reference this library of virus genes to recognize and attack viral invaders.

Qi and colleagues used a protein from this system, called Cas9, as a chassis into which they can insert any specific RNA partner molecule. The selected RNA serves as an adaptor that determines the target anywhere within the genome. "Targeting the machinery to new sites is extremely flexible and quick," Qi said.

The research team was able to get the system to work in mammalian cells as well as bacterial cells, and is working to improve its efficiency in mammalian cells, including human cells. The team aims to couple the Cas9 chassis to an enzyme that will enable the technology to turn genes on as well as off.

Such a versatile tool could prove valuable in efforts to reprogram cells for regenerative medicine. Lim's own lab is working on reprogramming immune cells to treat cancer.

"The idea is to reprogram cells to do the things we want them to do," Lim said. "We are still unlocking the secrets of the genome to harness the power of cellular reprogramming."

Additional UCSF co-authors of the Feb. 28 Cell study are postdoctoral fellows Matthew Larson, PhD, and Luke Gilbert, PhD. UC Berkeley co-authors are Adam Arkin, PhD, professor of bioengineering; and Jennifer Doudna, PhD, Howard Hughes Medical Investigator and professor of biochemistry. All the study authors are members of QB3, the California Institute for Quantitative Biosciences, which is headquartered at UCSF Mission Bay.

The research was funded by the National Institutes of Health, the Howard Hughes Medical Institute and the National Science Foundation.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of California - San Francisco. The original article was written by Jeffrey Norris.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Lei?S. Qi, Matthew?H. Larson, Luke?A. Gilbert, Jennifer?A. Doudna, Jonathan?S. Weissman, Adam?P. Arkin, Wendell?A. Lim. Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression. Cell, 2013; 152 (5): 1173 DOI: 10.1016/j.cell.2013.02.022

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/fWzP4VyhFSU/130307190645.htm

three stooges the three stooges the bee gees woodward keratosis pilaris rock and roll hall of fame 2012 brandon rios